Potent Cyclic Urea HIV Protease Inhibitors with Benzofused Heterocycles as P2/P2′ Groups.

James D. Rodgers,Barry L. Johnson,Haisheng Wang,Roger A. Greenberg,Susan Erickson-Viitanen, Ronald M. Klabe,Beverly C. Cordova,M. M. Rayner,Gilbert N. Lam,Chong-Hwan Chang

ChemInform（1997）

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Abstract A series of benzofused heterocycles was examined to replace the metabolically unstable benzyl alcohol P2/P2′ groups of DMP 323 (1). Extremely potent inhibitors of HIV protease (Ki

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