A convenient synthesis of 2-amino-2-oxazolines and their pharmacological evaluation at cloned human α adrenergic receptors

Wai C. Wong,Diana Wang,Carlos Forray,Pierre J.-J. Vaysse,Theresa A. Branchek,Charles Gluchowski

ChemInform（1994）

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摘要

A number of 2-amino-2-oxazolines including rilmenidine (7) were synthesized in good yield by thermal cyclization of 2-chloroethylurea 2 in the presence of potassium fluoride on alumina. These compounds were assayed for their binding affinity and efficacy at cloned human α adrenergic receptors.

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