Part 1: design, synthesis and evaluation of new site-specific monoamine oxidase inhibitors
Bulletin of Pharmaceutical Sciences. Assiut(1998)
摘要
Certain new monoamine oxidase inhibitors (MAOIs) containing a pyridinium moiety as an integral part of their structures (Q) were designed. The quaternaries, their corresponding 1,4-dihydroxypyridine derivatives (CDS) and their parent pyridine compounds (P) were synthesized. A spectrofluorimetric method was used to test their in vitro monoamine oxidase inhibition. The compounds showed reasonable activities by the test performed.
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