Effects of supplemented Taohe Chengqi DecoctionOpen image in new window in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus) in treating insulin resistance in rats with non-insulin Dependent Diabetes Mellitus

Objective: To investigate the effect of supplemented Taohe Chengqi Decoction ( Open image in new window , STHCQD) in treating non-insulin dependent diabetes mellitus (NIDDM).Methods: The model of rats with NIDDM was formed with injection of streptozotocin and fed on high calorie diet to study the effects of STHCQD on the release of insulin sensitivity.Results: (1) Fasting serum glucose, serum insulin, intake of food and water were significantly decreased (P < 0.05- 0.01) in STHCQD-treated diabetic rats as compared with untreated diabetic rats, while the insulin sensitivity was significantly increased (P < 0.05). (2) The liver cell membranes from STHCQD-treated diabetic rats released the quantity of insulin receptor which inhibited adenylate cyclase activity, but this effect was blunted in untreated diabetic rats (P < 0.05). (3) A significantly increased glucose oxidation in adipocyte of STHCQD-treated diabetic rats was found as compared with those of untreated diabetic rats (P < 0.05).Conclusions: STHCQD therapy increased sensitivity and responsiveness of target cells to insulin, i.e. it might decrease insulin resistance at receptor sites and post-receptor sites in rats with NIDDM, but could not reverse the insulin resistance.