Biologically Selective Potassium Channel Openers Having 1,1‐Diethylpropyl Group.

Kazuya Yoshiizumi,Norihiko Seko,Noriyasu Nishimura,Shoji Ikeda,Kohichiro Yoshino,Hirosato Kondo,Kazutaka Tanizawa

ChemInform（1999）

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摘要

To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

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