Synthesis and characterization of some peptides having surface activity using polyethylene glycol

In order to obtain peptide based amphoteric surfactants with antimicrobial activity, six polyethylene glycol bounded peptide chains were synthesized using the liquid phase method. The investigated chains contain aliphatic and aromatic amino acids in different sequences. Polyethylene glycol monomethyl ether was empolyed as soluble polymeric support; dicyclohexyl carbodiimide was used as the coupling reagent while the acid labile tert. butyloxy carbonyl group was applied in N-protection. The synthesized peptide chains was found to have promising surface properties beside their antimicrobial activity.