Nasopharyngeal and serological anti SARS-CoV-2 IgG/IgA responses in COVID-19 patients

Bernadette Crescenzo-Chaigne,Sylvie Behillil,Vincent Enouf,Nicolas Escriou,Stephane Petres,Marie Noelle Ungeheuer,Jade Ghosn,Sarah Tubiana,Lila Bouadma,Sylvie van der Werf,Caroline Demeret

Journal of Clinical Virology Plus（2021）

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摘要

•An IgG and IgA -mediated humoral response directed against the N and S antigens is detected in the nasopharyngeal swabs of 2 severe COVID-19 patients but not in 2 pauci-symptomatic patients.•Anti-N and anti-S serological responses differ according to the disease outcome, with reduced IgG response and enhanced anti-N IgA response in severe patient with fatal disease.•Low serological response occurred in pauci-symptomatic patients, predominated by anti-S antibodies.

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SARS CoV,Mucosal Immunity,Serology

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