Discovery and Optimization of Biaryl Alkyl Ethers As a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain. Guanglin Luo , Ling Chen , Walter A. Kostich , Brian Hamman , Jason Allen , Amy Easton , Clotilde Bourin , Michael Gulianello , Jonathan Lippy , Susheel Nara , Sreenivasulu Naidu Pattipati , Kumaran Dandapani , Manoj Dokania , Pradeep Vattikundala , Vivek Sharma , Saravanan Elavazhagan , Manoj Kumar Verma , Manish Lal Das , Santosh Wagh , Anand Balakrishnan , Benjamin M. Johnson , Kenneth S. Santone , George Thalody , Rex Denton , Hariharan Saminathan , Vinay K. Holenarsipur , Anoop Kumar , Abhijith Rao , Siva Prasad Putlur , Sarat Kumar Sarvasiddhi , Ganesh Shankar , Justin Louis , Manjunath Ramarao , Charles M. Conway , Yu-Wen Li , Rick Pieschl , Yuan Tian , Yang Hong , Linda Bristow , Charles F. Albright , Joanne J. Bronson , John E. Macor , Carolyn D. Dzierba Journal of Medicinal Chemistry(2022)
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