Genetic determinants of intracranial large artery stenosis in the northern Manhattan study

Minghua Liu,Sanjeev Sariya,Farid Khasiyev,Giuseppe Tosto,Nicole D Dueker,Ying Kuen Cheung,Clinton B Wright,Ralph L Sacco,Tatjana Rundek,Mitchell S V Elkind,Jose Gutierrez

Journal of the Neurological Sciences（2022）

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摘要

•Intracranial large artery stenosis (ILAS) represents the most advanced stage of intracranial atherosclerotic disease.•CYP11B2 rs1799998 was associated with ILAS prevalence.•The risk of ILAS associated with LPL rs320.•The genotype distributions of ADIPOQ, APOE and CYP11B2 variants varies by race/ethnic group.

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关键词

Intracranial large artery stenosis,Aldosterone synthase,Lipoprotein lipase,Epidemiologic studies,Genetic predisposition to disease

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