How many molecules of mitochondrial complex I are in a cell?

Fariha Ansari,Belem Yoval,Zoya Niatsetskaya,Vadim Ten,Ilka Wittig,Alexander Galkin

Analytical Biochemistry（2022）

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摘要

Mitochondrial complex I is the only enzyme responsible for oxidation of matrix NADH and regeneration of NAD+ for catabolism. Nuclear and mtDNA mutations, assembly impairments, and enzyme damage are implicated in inherited diseases, ischemia-reperfusion injury, neurodegeneration, and tumorogenesis.

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关键词

Mitochondrial complex I,Flavin mononucleotide,Fluorescence,Respiratory chain,Astrocytes

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