One-Pot Reductive-Cyclization as Key Step for the Synthesis of Rutaecarpine Alkaloids.

Abstract The quinazolinocarboline alkaloids including rutaecarpine (1a), euxylophoricine A (1b), and euxylophoricine C (1c) have been synthesized efficiently from the ring opened β-carboline derivative as key intermediate by a one-pot reductive-cyclization reaction. The key intermediate was prepared from tryptamine (6) following Bischler–Napieralski cyclization, benzoylation, and oxidative cleavage of the exocyclic double bond.