One-pot Synthesis and Biodistribution of 6-[~(18)F]Fluoro-6-deoxy-D-glucose(6-~(18)FDG) as Potential Glucose Transport Imaging Agent

For the development glucose transport imaging,a radioactive glucose analogue was synthesized and evaluated.A glucose analogue,6-[18F]fluoro-6-deoxy-D-glucose(6-18FDG),was prepared in two steps with one-pot synthesis from [18F]fluoride and tosyl-precursor.Starting with D-glucose,the D-glucose was reacted with acetone and benzaldehyde to protect hydoxy,then reacted with p-toluenesulfonyl choride(TsCl)to get the tosyl-precursor.All the intermediates were identified with NMR and MS.The total radiosysthesis spent 35 min and with 70%±5%(EOB,decay corrected,n =5),with the radiochemical purity95%.Biodistribution of 6-18FDG was performed in mice:18F activities in brain,liver,and heart reach the peak in 1.0 min after the injection,so reached a constant level.These results support that 6-18FDG is promising as valid tracer of glucose transport.