Straightforward Synthesis of Triazoloacyclonucleotide Phosphonates as Potential HCV Inhibitors.
ChemInform(2011)
摘要
Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide-alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies.
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