Novel 2,3,4,5‐Tetrahydro‐benzo[d]azepine Derivatives of 2,4‐Diaminopyrimidine, Selective and Orally Bioavailable ALK Inhibitors with Antitumor Efficacy in ALCL Mouse Models.
ChemInform（2011）
摘要
The synthesis and biological evaluation of potent and selective anaplastic lymphoma kinase (ALK) inhibitors from a novel class of 2,4-diaminopyrimidines, incorporating 2,3,4,5-tetrahydro-benzo[d]azepine fragments, is described.
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