Clinical observation on combined chemo-radiotherapy in high grade intracranial glioma

Objective To evaluate the efficacy of postoperative concurrent radiochemotherapy for high grade intracranial glioma. Methods 117 cases of postoperative intracranial glioma were randomized into observation group (58 cases) and control group (59 cases). In the control group, routine postoperative external irradiation were administered with a total dose of 60 Gy/6weeks. In the observation group, chemotherapy was concurrently with radiotherapy. When the irradiative dose was 20 to 30 Gy, patients received Me-CCNU 150 mg orally, followed by once every week, the total cycles were three to four during the radiation and the total cycles were six to eight.Results The local response rate of the observation group and control group was 68.97% and 25.42%,respectively. There was significant difference between them(P0.01).Median recurrent time was 14.25 months in the observation group and 10.38 months in the control group(P0.01). The 1-,2-,3-,4 year survival rates were 72.41%,43.10%,22.41%,12.09%, in the observation group and 49.15%,15.25%,10.17%,1.69%, in the control group,respectively. There was statistic significance of the difference between the two groups in 2-year survival rate(P0.05).The acute toxicity was more serious in the observation group. The late toxicity was approximate in both groups. Conclusion Postoperative concurrent radiochemotherapy is able to improve the local control rate and prolong the recurrent time for the patients with high grade intracranial glioma.It is able to improve survival rate.