A Synthetic Approach to the Glycan Chain of High Mannose Type N-Glycoprotein.

Abstract The syntheses of α-D-glucopyranose-(1→3)-D-mannopyranose, methyl α-D-glucopyranose-(1→3)-α-D-mannopyranoside and methyl α-D-glucopyranose-(1→3)-α-D-mannopyranose-(1→2)-α-D-mannopyranoside are reported. High stereoselectivity was observed during the coupling of glucose and mannose residues by the use of glucosyl trichloroacetimidate as donor.