Brm expression in gastric cancer and its clinical significance

Objective To investigate the BRM expression in gastric carcinoma and the relationship between the happening of gastric cancer and clinicopathologic feature.Methods By using immunohistochemical method,check the BRM expression in 69 cases of gastric cancers and 71 cases of normal gastric tissue as controls.Moreover,the relationship between the levels of BRM expression and histologic and clinical features was also analysed in gastric cancer.Results The positive rate of Brm immunostaining in gastric cancers showed an obvious reduction as compared with that in the normal gastric tissues(P0.05).Moreover,such a variation of Brm expression was related to the differentiation state,invasion degree,lymphonode metastasis and clinical stages of the gastric cancers.Conclusions The results indicate that Brm expression reduction may play an important role in the development of gastric carcinoma.Meanwhile,Brm may be used as a valid marker in determining the clinical prognosis of gastric carcinoma.