Retraction Note to: Genetic polymorphisms in the CYP1A1 and CYP1B1 genes and susceptibility to bladder cancer: a meta-analysis.
Molecular Biology Reports(2014)
摘要
The current meta-analysis of case–control studies was conducted to evaluated the
relationships of genetic polymorphisms in the CYP1A1 and CYP1B1 genes with the
susceptibility to bladder cancer, aiming at determine whether these polymorphisms
may contribute to the pathogenesis of bladder cancer. Related articles were
determined via searching the following electronic databases without any language
restrictions: PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO,
Cochrane Library, and CBM databases for relevant articles published before November
1st, 2013. STATA 12.0 software was also selected to deal with statistical data. The
relationships were evaluated using the pooled odds ratios (ORs) and their 95 %
confidence intervals (CI). Eleven case–control studies with a total of 2,609 bladder
cancer patients and 2,634 healthy subjects met the inclusion criteria. The results
of our meta-analysis demonstrated that CYP1A1
genetic polymorphisms were associated with increased risks of bladder cancer (allele
model: RR = 1.18, 95 % CI 1.07–1.30, P = 0.001;
dominant model: RR = 1.15, 95 % CI 1.05–1.27, P = 0.003; respectively), especially among 11599G>C, 2455A>G,
3810T>C, and 113T>C polymorphisms. A subgroup analysis by ethnicity was
conducted to investigate its effect on susceptibility to bladder cancer. The
subgroup analysis results revealed positive significant correlations between
CYP1A1 genetic polymorphisms and bladder
cancer risk among Asians (allele model: RR = 1.26, 95 % CI 1.10–1.44, P = 0.001; dominant model: RR = 1.22, 95 % CI
1.08–1.38, P = 0.001), but not among Caucasians
(all P < 0.05). Nevertheless, we observed no
significant correlations between CYP1B1 genetic
polymorphisms and bladder cancer risk (all P > 0.05). Our meta-analysis indicates that CYP1A1 genetic polymorphisms may be involved in the pathogenesis of
bladder cancer, especially among 11599G>C, 2455A>G, 3810T>C, and 113T>C
polymorphisms. However, CYP1B1 genetic
polymorphisms may not be important determinants of bladder cancer
susceptibility.
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