The effects of XinFeng capsule on B and T lymphocyte attenuator and oxidative stress of knee osteoarthritis patients

This study aimed to observe the effects of XinFeng capsule(XFC) on the expression of B and T lymphocyte attenuator(BTLA) and superoxide dismutase(SOD) in knee osteoarthritis(KOA).Total of 60 patients with KOA were randomly divided into XFC group and glucosamine(GS) group.Then we used flow cytometry to detect BTLA level,colorimetric assay to detect SOD level,and ELISA to detect the levels of methane dicarboxylic aldehyde(MDA),IL-10,and IL-1β in patients.The expression of BTLA and SOD were significantly decreased but MAD were significantly increased in KOA patients compared with normal individuals,and the expression of BTLA was negatively related to Lequesne MG and IL-1β level,while positively related to RP,RE,BP,and IL-10 levels. Furthermore,CD4 + BTLA + T cell was positively related to SOD level.After treatment,we found that XFC can significantly increased SF-36 scores,BTLA and IL-10 levels,while decreased Lequesne MG,symptom classify quantization scores,IL-1β and MDA levels.All above results suggested that XFC can reduce abnormal immune response and alleviate oxidative stress injury, thus finally improve the quality of life of KOA patients.