Pyrrolidine‐Oxyimides: New Chiral Catalysts for Enantioselective Michael Addition of Ketones to Nitroolefins in Water.

Abstract A new class of proline based organocatalysts ‘pyrrolidine-oxyimides’ were designed and synthesized from l -proline and hydroxyimides by employing a simple reaction protocol. These catalysts were found to be efficient in promoting asymmetric Michael additions of ketones to nitroolefins at room temperature. Good yields and high selectivities were obtained with catalyst 1a under additive-free conditions employing water as the reaction medium.