Keratinocyte growth factor treatment prevents radiation-induced intestinal damage in a mouse model

Objective To study protective effect of keratinocyte growth factor(KGF) in radiation-induced intestinal injury in a mouse model.Methods The C57BL /6J mice were randomly divided into five groups: control group,radiation group and low,middle,high dose groups of KGF(1,2,4 mg / kg).The control group were shamirradiated,other groups were given a single whole body irradiation at the dose of 7.2 Gy with137CS-γ rays.Then body weight were measured,protein,NO concentrations and pathology were observed in intestinal.Results Compared with simple IR group,KGF treatment groups showed better status in body weight and pathology of intestinal,KGF low,middle dose groups with protein concentrations had statistically significant(P 0.05),KGF high dose group with protein concentrations had statistically significant(P 0.01),KGF middle,high dose groups with NO concentrations had statistically significant(P 0.05).Conclusion KGF treatment could improve radiation-induced intestinal injury in a mouse model.