Vertical gradients in regional alveolar oxygen tension in supine human lung imaged by hyperpolarized 3He MRI

Hooman Hamedani,Hoora Shaghaghi,Stephen Kadlecek,Yi Xin,Biao Han,Sarmad Siddiqui,Jennia Rajaei,Masaru Ishii,Milton D. Rossman,Rahim R. Rizi

NMR in Biomedicine（2014）

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摘要

Purpose To evaluate whether regional alveolar oxygen tension (PAO2) vertical gradients imaged with hyperpolarized 3He can identify smoking-induced pulmonary alterations. To compare these gradients with common clinical measurements including pulmonary function tests, the six minute walk test, and the St. George’s Respiratory Questionnaire.

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