Recent Application of Oxa-Michael Reaction in Complex Natural Product Synthesis

Abstract The strategy of employing oxa-Michael reaction in today’s organic synthesis appears to be a big success due to its high efficiency in the construction of C O bonds. In this digest, recent advances of its application in the total synthesis of representative oxygen-containing natural products, involving macrolides, terpenoids, chromanones and chromanes, polyoxygenated molecules and alkaloids et al. are discussed, with the aim of providing a complement to existing reviews.