TNFR2 is critical for TNF-induced rheumatoid arthritis fibroblast-like synoviocyte inflammation.

Takahito Suto,Anela Tosevska,Karolina Dalwigk, Maximillian Kugler,Mirjam Dellinger,Irena Stanic,Alexander Platzer,Birgit Niederreiter,Florian Sevelda,Michael Bonelli,Thomas Pap,Hans Kiener,Koichi Okamura,Hirotaka Chikuda,Daniel Aletaha,Leonhard X Heinz,Thomas Karonitsch

Rheumatology (Oxford, England)（2022）

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摘要

Our results define a critical role for TNFR2 in FLS-driven inflammation and unfold its participation in the unresolved course of synovial inflammation in RA.

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关键词

RA,STAT1,TNF,TNF-receptor (TNFR),fibroblast-like synoviocytes (FLS),synovitis

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