Formulasi dan Uji Penetrasi Sediaan Gel Transfersom yang Mengandung Kojyl 3 Amino Propil Fosfat sebagai Pencerah Kulit

Kojyl 3 APPA is a compoun d used for skin lightening . Kojyl 3 APPA has a good solubility in water. This causes the hydrophilic nature k ojyl 3 APPA difficult to penetrate through the skin. Transfersom is a carrier system that can improve the effectiveness of drug penetration. This study aims to formulate, characterize and evaluate transfersom preparations containing kojyl 3 APPA. Further more transfersom formulated in a gel formulation. Preparation gel was tested its physical stability an d in vitro penetration tes t against non transfersom kojyl 3 APPA . Transfersom gel formulation is physically proven stable at room temperature, low temperature and high temperature storage . In vitro penetration tests show ed that k ojy l 3 APPA penetration loaded in transfersom gel was 11,16% while for non transfersom gel 8,02%.