Highly Efficient and Regioselective Synthesis of Spirooxindolo Pyrrolizidines by Reaction of Isatin, Proline and Acrylonitrile/Methyl Acrylate in Water.

Keshri Nath Tiwari,Taur Prakash Pandurang,Suyash Pant,Rahul Kumar

ChemInform（2016）

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摘要

The 1,3-dipolar cycloaddition reaction of azomethine ylides generated in situ by isatin and L-proline to acrylonitrile and methyl acrylate in water affords a series of spirooxindolo pyrrolizidines in good yields.

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