Increased ROS-Mediated CaMKII Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome

Xujie Liu,Suya Wang,Xiaoling Guo,Yifei Li,Roza Ogurlu,Fujian Lu,Maksymilian Prondzynski,Sofia de la Serna Buzon,Qing Ma,Donghui Zhang,Gang Wang,Justin Cotton,Yuxuan Guo,Ling Xiao,David J. Milan,Yang Xu,Michael Schlame,Vassilios J. Bezzerides,William T. Pu

Circulation（2021）

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摘要

Background: Mutations in tafazzin (TAZ), a gene required for biogenesis of cardiolipin, the signature phospholipid of the inner mitochondrial membrane, causes Barth syndrome (BTHS). Cardiomyopathy ...

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