Ryanodine Receptor Inhibition Prevents Sudden Cardiac Death by Preserving Cardiac Repolarization Reserve in Stressed Arrhythmogenic Hearts

Pooja Joshi,Babunageswararao Kanuri,Jeffrey S. Crocker,Sonia Y. Byon,Deeptankar DeMazumder, Bjorn C. Knollmann,Swati Dey

Circulation（2021）

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摘要

Introduction: Current therapies for preventing sudden cardiac death (SCD) are limited. Prior studies have shown that cardiac stress-induced ryanodine receptor (RyR2) hyperactivity increases sarcopl...

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