Synthesis, Crystal Structure, and Evaluation of Biologycal Activity of Novel Heterocyclic Derivative of 8-Hydroxyquinoline

Younes Lakhrissi,Mohamed Rbaa, Meriem Mequedade,Inssaf Berkiks, Joel T. Mague,Aboubaker El Hessni,Youssef Ramli,Faisal A. Almalki,Taibi Ben Hadda,Brahim Lakhrissi

Social Science Research Network（2020）

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摘要

In this study, a new derivative of 8-hydroxyquinoline has been synthesized, and characterized by 1H/13C NMR, IR, elemental analysis, and X-ray crystallography. The potential anti-anxiety, and anti-depressant effects of intraperitoneal administration of 5-(((2-hydroxy-ethyl) thio) methyl)quinolin-8-ol were evaluated using the behavioral tests: Open Field Test (OFT), Elevated Plus-Maze (EPM) test, and Forced Swim Test (FST).

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