Abstract 13952: A Novel Genetic Mini-Pig Model of Cardiac Myosin-Binding Protein C (MYBPC3) Dysfunction: Evidence for Altered Sarcomere Structure and Systolic/Diastolic Functional Reserve in vivo

Carlos del Rio,Weikang Ma,David M. Ryba,Henry Gong, Marcus Henze,Sampath K. Gollapudi,Robert M. Anderson,Suman Nag, Chris A Rogers,Thomas C. Irving

Circulation（2021）

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摘要

Introduction: Mutations in MYPBC3, the gene encoding cardiac Myosin-Binding Protein C (cMyBP-C), a regulatory sarcomeric protein, are known to play a pathogenic role in hypertrophic cardiomyopathy ...

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