The feasibility of multi-mode fiber based speckle contrast optical spectroscopy

Speckle contrast optical spectroscopy/tomography (SCOS/SCOT) is a low-cost, non-invasive, and real-time optical imaging modality for measuring cerebral blood flow with increased signal-to-noise ratio relative to diffuse correlation spectroscopy. However, the recent camera-based detector system is not ideal for imaging a large area of the human brain because of the limited area of focus over the contour of the head and hair occluding the field of view. Here we demonstrated the feasibility of using inexpensive multi-mode fiber bundles to build a SCOS system for mapping the flow of fluids, and we showed a statistical method for distinguishing noise and speckle signals.