B Lymphocytes, but Not Dendritic Cells, Efficiently HIV-1 Trans Infect Naive CD4 ⁺ T Cells: Implications for the Viral Reservoir

Abigail Gerberick,Diana C. DeLucia,Paolo Piazza,Mounia Alaoui-El-Azher,Charles R. Rinaldo,Nicolas Sluis-Cremer,Giovanna Rappocciolo

MBio（2021）

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摘要

The latent human immunodeficiency virus type 1 (HIV-1) reservoir in persons on antiretroviral therapy (ART) represents a major barrier to a cure. Although most studies have focused on the HIV-1 reservoir in the memory T cell subset, replication-competent HIV-1 has been isolated from T N , and CCR5-tropic HIV-1 has been recovered from CCR5 neg T N from ART-suppressed HIV-1-infected individuals.

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lymphocytes,dendritic cells,infect naive cd4

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B Lymphocytes, but Not Dendritic Cells, Efficiently HIV-1 Trans Infect Naive CD4 + T Cells: Implications for the Viral Reservoir

B Lymphocytes, but Not Dendritic Cells, Efficiently HIV-1 Trans Infect Naive CD4 ⁺ T Cells: Implications for the Viral Reservoir