Intraoperative FLIm for pathology detection and surgical guidance in oral and oropharyngeal cancer patients
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX(2021)
摘要
Oral cavity and oropharyngeal cancers are leading pathologies, representing 3% of all new cancer cases in the United States. Adequate intraoperative marginal clearance of these malignancies is essential for long-term survival; however, presently available techniques limit precise instantaneous tumor margin characterization. Herein, we report the clinical validation of a fiber-based fluorescence lifetime imaging device for real-time intraoperative tumor delineation. Results from 72 human patients are reported (autofluorescence trends, ROC-AUC), including diverse cancer histologies, anatomic sites (e.g. tongue, tonsil, etc.), and patient medical histories. Emphasis is placed on results governing the detection of unknown primary tumors from 4 patients, as well as data from 5 patients presenting with residual carcinoma.
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