Solid‐State Nanochannels: Enzyme and AIEgens Modulated Solid‐State Nanochannels: In Situ and Noninvasive Monitoring of H2O2 Released from Living Cells (Small Methods 2/2020)

In article number 1900432 by Fan Xia and co-workers, living cells are first incubated on a flexible polyethylene terephthalate (PET) membrane and then inserted into the left chamber of a nanochannels device. When H2O2 is released from living cells, a Tyr-containing tetraphenylethylene (TPE) derivative (TT) forms horseradish peroxidase (HRP)-modulated linkage in the nanochannels, which is covalently attached to capture probes. By using this dual-signaloutput (ionic current and fluorescence) nanochannel device, in situ and noninvasive detection of H2O2 can be achieved.