Abstract 13835: MG53 Preserves Mitochondrial Integrity of Cardiomyocytes in Pre-Clinical Models of Ischemia Reperfusion-Induced Oxidative Stress

Hua Zhu,Kristyn Gumpper,Hanley Ma,Xinyu Zhou,Zehua Bian,Karthikeyan Krishnamurthy,Ki Ho Park,Matthew Sermersheim,Jingsong Zhou,Tao Tan, Lei Li,Jian-Xun Liu,Pei-Hui Lin,Jianjie Ma

Circulation（2021）

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摘要

Introduction: Ischemic injury to the heart induces mitochondrial dysfunction due to an increase in oxidative stress. MG53, also known as TRIM72, is highly expressed in striated muscle and is essent...

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