Combined Assessments of Monogenic and Polygenic Risk for Dilated Cardiomyopathy

Krishna G. Aragam,Kiran Biddinger,Sean J. Jurgens,Minxian Wang,James Pirruccello,Dimitri Maamari,Mark Chaffin,Seung H. Choi, Valerie Morrill,Christopher Newton-cheh,Amit V. Khera,Steven A. Lubitz,Patrick T. Ellinor

Circulation（2021）

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摘要

Introduction: Genetic testing for non-ischemic dilated cardiomyopathy (DCM) currently comprises assessment of rare (monogenic) mutations in DCM-relevant genes. The role of a common-variant (polygen...

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