Proteomic Analysis During Pediatric Extracorporeal Membrane Oxygenation Reveals Modulation of Key Coagulation and Immune Process Proteins

Purpose Clinicians managing infants requiring extracorporeal membrane oxygenation (ECMO) are presented with unique challenges due to the intense inflammatory response and associated effects on coagulation. Plasma proteomics provides a global evaluation of proteins leading to identification of therapeutic targets. We used a highly multiplexed aptamer-based proteomic approach to identify changes in protein expression from plasma samples of children on ECMO. Methods All children requiring ECMO were …