Deletion of the Type I Interleukin-1 Receptor Prevents the Development of Cardiomyopathy Associated With Aging in Mice

Pratyush Narayan,Elefterios Trikantzopoulos,Eleonora Mezzaroma,Adolfo G. Mauro,Habeebah Vohra,Antonio Abbate,Stefano A. Toldo

Circulation（2021）

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摘要

Background: Aging is associated with metabolic and structural changes causing heart failure with preserved ejection fraction (HFpEF). Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in...

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