Predictive utility of tuberculosis symptom screening for children and adolescents living with HIV in six high HIV/TB burden countries in eastern and southern Africa.

BACKGROUND: The World Health Organization (WHO) estimates tuberculosis (TB) accounted for 40,000 deaths in children living with HIV in 2017. Early detection and treatment of TB reduces mortality in children and adolescents living with HIV (CALHIV). Despite limited evidence, the WHO recommends that CALHIV are actively screened for TB symptoms at every clinical encounter in order to improve TB case detection. As more CALHIV access care and …