Genetic Deletion of Interleukin-22 Prevents Angiotensin II-Induced Cardiac Diastolic Dysfunction in Mouse

Mai Yamamoto,Hideo Yasukawa,Jinya Takahashi,Shoichiro Nohara, Tomoko Minami,Tatsuhiro Shibata,Toshiyuki Yanai,Kota Okabe,Daiki Akagaki,Yoshihiro Fukumoto

Circulation（2021）

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摘要

Introduction: Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, which promotes STAT3 activation in targets cells. Although it has been shown that persistent activation of STAT3 cause...

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