Abstract 9081: Fatal Occlusive Pulmonary Vasculopathy in Rats Late After Perinatal Hypoxia: Hyperproliferative and Pro-Inflammatory Phenotypes and Related Differential Dna Methylation in Cultured Pulmonary Arterial Smooth Muscle Cells as the Potential Substrate

Hironori Oshita,Hirofumi Sawada,Yoshihide Mitani,Naoki Tsuboya, Jane Kabwe,Junko Maruyama,Ali Yusuf,Hiromasa Ito,Ryuji Okamoto,Noriko Yodoya,Shoichiro Otsuki,Hiroyuki Ohashi, Kazunobu Oya,Yuhko Kobayashi, Issei Kobayashi,Kaoru Dohi,Yuhei Nishimura,Shinji Saitoh,Sawada Hirofumi,Masahiro Hirayama

Circulation（2021）

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摘要

Background: Perinatal insults increase the risk of developing various adult-onset vascular diseases. Although we recently established a fatal SU5416/hypoxia-induced model with worsening pulmonary v...

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perinatal hypoxia,fatal occlusive pulmonary vasculopathy,related differential dna methylation,pro-inflammatory

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