16alpha-Hydroxyestrone Downregulates SOX17 During the Development of Pulmonary Arterial Hypertension

Shreya Sangam,Tae-Hwi Schwantes-An, John Zagorski,Yinan Shi,Seth Morrisroe, Todd Cook,Amanda Fisher,Andrea Frump,Anna Coleman,Haiyang Tang,Howard Crawford,Katie Lutz

Circulation（2021）

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摘要

Introduction: Sexual dimorphism in pulmonary arterial hypertension (PAH) is attributed, in part, to estrogen signaling. 16α-hydroxyestrone (16αOHE) is considered a major contributor to PAH pathogen...

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