Cell-Specific Regulation of the GATA-4/6 Transcription Factors by the Metabolic Enzyme PKM2 Provides Insight into a Biologic Function Essential for Cardiac Health and Survival

Maria Areli Lorenzana Carrillo,Keshav Gopal,Nikole J. Byrne,Bruno Saleme,Subhash K. Das,Saymon Tejay,Yongneng Zhang,Alois S. Haromy,Farah Eaton,Jason R. Dyck,Evangelos D. Michelakis,Gopinath Sutendra

Circulation（2021）

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摘要

Background: Pyruvate Kinase M2 (PKM2) is a glycolytic enzyme that can translocate to the nucleus and regulate different transcription factors (TF). Although its function has been studied extensivel...

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