CES1 Deficiency is Associated With Oxidative Stress and Endoplasmic Reticulum/Mitochondrial Injury in Pulmonary Endothelial Cells

Stuti Agarwal,Ananya Chakraborty,David Condon, Elya Shamskhou,Hiral Patel,Lichao Liu,James West,Karthik Suresh,Bruce D. Hammock,Marlene Rabinovitch,Joseph C. Wu,Mark Nicolls

Circulation（2021）

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摘要

Background: Pulmonary Arterial Hypertension (PAH) is a life-threatening disease characterized by loss of pulmonary microvessels and vascular remodeling. BMPR2 insufficiency in PAH is associated wit...

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