Design, synthesis and anticancer evaluation of chalcone based thieno[2,3-d]thiazoles as anticancer agents

A new series of aryl chalcone incorporated thieno[2,3-d]thiazoles (10a-j) have been designed and synthesized and their structures were confirmed by analytical data. Further, these derivatives were screened for their anticancer activity towards four human cancer cell lines such as prostate cancer (PC3), lung cancer (A549), breast cancer (MCF-7) and ovarian cancer (A2780) by employing of MTT assay. The obtained results were compared with standard drug as etoposide. Among the tested derivatives, five derivatives (10a, 10d, 10e, 10f and 10j) were revealed most promising activities Specifically, two compounds 10d (PC3=0.77±0.032 µM; A549=0.078±0.0051 µM; MCF-7 = 0.44±0.061 µM and A2780=1.46±0.92 µM) and 10e (PC3=0.03±0.0063 µM; A549=0.021±0.0075 µM; MCF-7 = 0.19±0.084 µM and A2780=0.11±0.064 µM) possessed highest anticancer activity.