Myocardial Contractile Dysfunction and Anti-Troponin I Immunoreactivity in a Mouse Model of Combination Immune Checkpoint Inhibitors

Shirley Xu,Badri Karthikeyan,Peninah Pechenik,Sharma Kattel,Joseph Spernyak, Steven Turowski,Swati D. Sonkawade,Sarmila Nepali,Umesh C. Sharma,Saraswati Pokharel

Circulation（2021）

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摘要

Introduction: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of many incurable cancers. However, serious cardiotoxic side effects, such as fatal myocarditis, have been report...

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