Molecular Cloning and Characterization of a Novel Antimicrobial Peptide from the Skin of Kaloula pulchra .

Yahua Gao,Jinwei Chai,Jiena Wu,Qingye Zeng,Ruiyin Guo,Xin Chen,Xueqing Xu

Current pharmaceutical biotechnology（2022）

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摘要

This is the first report on AMP identified from the skin of K. pulchra. Brevinin-2KP adopts a typical amphipathic α-helix conformation in membrane mimic environment and shows antimicrobial and antitumor activities by potential membranolytic mechanism. In addition, brevinin-2KP can promote degranulation and histamine release of mast cells. Brevinin-2KP is expected to become a good drug temple molecule.

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关键词

Antimicrobial peptide,Kaloula pulchra,amphibian,antitumor,brevinin-2,innate immunity

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