Zr-89-PSMA-617 PET/CT May Reveal Local Recurrence of Prostate Cancer Unidentified by Ga-68-PSMA-11 PET/CT

For localization of biochemical recurrence of prostate cancer, Ga-68-PSMA-11 PET/CT imaging was performed in a 66-year-old man with no suspicious findings at 1 hour p.i. Additional Zr-89-PSMA-617 PET/CT revealed a small local recurrence in the prostate bed, facilitating consecutive local therapy. This interesting image points to the potential of PET/CT with Zr-89-labeled PSMA ligands, for example, Zr-89-PSMA-617, for identifying the source of biochemical recurrence despite otherwise negative imaging including conventional PSMA PET/CT.