miR-205-5p in exosomes divided from chondrogenic mesenchymal stem cells alleviated rheumatoid arthritis via regulating MDM2 in fibroblast-like synoviocytes.

Wukai Ma,Fang Tang,Lina Xiao, Shan Han,Xueming Yao,Qiongyu Zhang, Jiayan Zhou,Yanjun Wang,Jing Zhou

Journal of musculoskeletal & neuronal interactions（2022）

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摘要

Chondrogenic BMSCs-derived exosomal miR-205-5p suppressed inflammatory response, MAPK and NF-κB pathways through MDM2 in RA, indicating exosomal miR-205-5p might be a potential target for RA treatment.

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关键词

BMSCs,Exosomes,MDM2,Rheumatoid Αrthritis,miR-205-5p

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