Antibiotic adverse effects in pediatric acute rhinosinusitis: Systematic review and meta-analysis

•Adverse events with oral antibiotic use in pediatric acute bacterial rhinosinusitis are low.•Diarrhea and abdominal pain are the most common adverse events; rash is relatively uncommon.•Adverse event rates for placebo and antibiotic groups are comparable, suggesting that some adverse events may be sequelae of ARBS infection.•Standardization of AE measurement and reporting methods would facilitate tracking of true adverse event incidence for common antibiotics.